- Education Topics
- Achievement Gap
- Alternative Education
- Assessment & Evaluation
- Educational Leadership
- Educational Philosophy
- Educational Research
- Educational Technology
- Educational Videos
- Education Economics
- Education Environment
- Education Issues
- Education Policy
- Education Psychology
- Education Reform
- Education Theory
- Education Worldwide
- Federal Education Legislation
- Homeless Education
- Homeschooling in the United States
- Migrant Education
- Neglected/Deliquent Students
- Pedagogy
- Sociology of Education
- Special Needs
- National Directories
- After School Programs
- Alternative Schools
- The Arts
- At-Risk Students
- Camps
- Camp Services
- Colleges & Universities
- Counties
- Driving Schools
- Educational Businesses
- Financial Aid
- Higher Education
- International Programs
- Jewish Community Centers
- K-12 Schools
- Language Studies
- Libraries
- Organizations
- Preschools
- Professional Development
- Prom Services
- School Assemblies
- School Districts
- School Field Trips
- School Health
- School Supplies
- School Travel
- School Vendors
- Schools Worldwide
- Special Education
- Special Needs
- Study Abroad
- Teaching Abroad
- Volunteer Programs
- Youth Sports
- For Schools
- Academic Standards
- Assembly Programs
- Blue Ribbon Schools Program
- Educational Accreditation
- Educational Television Channels
- Education in the United States
- History of Education in the United States
- Reading Education in the U.S.
- School Grades
- School Meal Programs
- School Types
- School Uniforms
- Special Education in the United States
- Systems of Formal Education
- U.S. Education Legislation
- For Teachers
- Academic Dishonesty
- Childcare State Licensing Requirements
- Classroom Management
- Education Subjects
- Educational Videos
- Interdisciplinary Teaching
- Job and Interview Tips
- Lesson Plans | Grades
- Professional Development
- State Curriculum Standards
- Substitute Teaching
- Teacher Salary
- Teacher Training Programs
- Teaching Methods
- Training and Certification
- For Students
- Academic Competitions
- Admissions Testing
- At-Risk Students
- Career Planning
- College Admissions
- Drivers License
- Educational Programs
- Educational Television
- Educational Videos
- High School Dropouts
- Higher Education
- School Health
- Senior Proms
- Sex Education
- Standardized Testing
- Student Financial Aid
- Student Television Stations
- Summer Learning Loss
Causes
The fragile X syndrome is a genetic disorder caused by mutation of the FMR1 gene on the X chromosome. Mutation at that site is found in 1 out of about every 1250 males and 1 out of about every 2500 females.
Normally, the FMR1 gene contains between 6 and 55 repeats of the CGG codon (tri nucleotide repeats). In people with the fragile X syndrome, the FMR1 allele has over 230 repeats of this codon.
Expansion of the CGG repeating codon to such a degree results in a methylation of that portion of the DNA, effectively silencing the expression of the FMR1 protein.
This methylation of the FMR1 locus in chromosome band Xq27.3 is believed to result in constriction and fragility of the X chromosome at that point, a phenomenon that gave the syndrome its name.
Mutation of the FMR1 gene leads to the transcriptional silencing of the fragile X-mental retardation protein, FMRP. In normal individuals, FMRP binds and facilitates the translation of a number of essential neuronal RNAs. In fragile X patients, however, these RNAs are not translated into proteins. The various sequelae of fragile X syndrome.
AF Sitemap
- Education Topics
- Achievement Gap
- Alternative Education
- Assessment & Evaluation
- Educational Leadership
- Educational Philosophy
- Educational Research
- Educational Technology
- Educational Videos
- Education Economics
- Education Environment
- Education Issues
- Education Policy
- Education Psychology
- Education Reform
- Education Theory
- Education Worldwide
- Federal Education Legislation
- Homeless Education
- Homeschooling in the United States
- Migrant Education
- Neglected/Deliquent Students
- Pedagogy
- Sociology of Education
- Special Needs
- National Directories
- After School Programs
- Alternative Schools
- The Arts
- At-Risk Students
- Camps
- Camp Services
- Colleges & Universities
- Counties
- Driving Schools
- Educational Businesses
- Financial Aid
- Higher Education
- International Programs
- Jewish Community Centers
- K-12 Schools
- Language Studies
- Libraries
- Organizations
- Preschools
- Professional Development
- Prom Services
- School Assemblies
- School Districts
- School Field Trips
- School Health
- School Supplies
- School Travel
- School Vendors
- Schools Worldwide
- Special Education
- Special Needs
- Study Abroad
- Teaching Abroad
- Volunteer Programs
- Youth Sports
- For Schools
- Academic Standards
- Assembly Programs
- Blue Ribbon Schools Program
- Educational Accreditation
- Educational Television Channels
- Education in the United States
- History of Education in the United States
- Reading Education in the U.S.
- School Grades
- School Meal Programs
- School Types
- School Uniforms
- Special Education in the United States
- Systems of Formal Education
- U.S. Education Legislation
- For Teachers
- Academic Dishonesty
- Childcare State Licensing Requirements
- Classroom Management
- Education Subjects
- Educational Videos
- Interdisciplinary Teaching
- Job and Interview Tips
- Lesson Plans | Grades
- Professional Development
- State Curriculum Standards
- Substitute Teaching
- Teacher Salary
- Teacher Training Programs
- Teaching Methods
- Training and Certification
- For Students
- Academic Competitions
- Admissions Testing
- At-Risk Students
- Career Planning
- College Admissions
- Drivers License
- Educational Programs
- Educational Television
- Educational Videos
- High School Dropouts
- Higher Education
- School Health
- Senior Proms
- Sex Education
- Standardized Testing
- Student Financial Aid
- Student Television Stations
- Summer Learning Loss